The effect of +Gz acceleration upon lactate, pyruvate and some nucleotides in the nervous tissue of the guinea pig.

The present paper was designed to the study of the effects of hypoxia induced by positive accelerations upon energy metabolism in the brain. Variations in the amount of lactate, pyruvate, ATP, ADP and AMP were determined immediately after centrifugation and after intervals of 30 to 90 minutes. An increase in the quantity of lactate and pyruvate, and a diminution of ATP running parallel to an increase in AMP were noted immediately after centrifugation. These variations almost entirely disappeared 90 minutes after centrifugation. These findings drew attention to a possible imbalance of the neuronal energy processes, which might bring about, even for short periods, alteration of the neuronal function.