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蜡样芽孢杆菌的膜结合5'-核苷酸酶/核苷磷酸转移酶

Membrane-bound 5'-nucleotidase/nucleoside phosphotransferase from Bacillus cereus.

作者信息

Baiocchi C, Pesi R, Turriani M, Tozzi M G, Camici M, Ipata P L

机构信息

Dipartimento di Fisiologia e Biochimica, Università di Pisa, Italy.

出版信息

Int J Biochem. 1993 Nov;25(11):1625-9. doi: 10.1016/0020-711x(93)90521-f.

DOI:10.1016/0020-711x(93)90521-f
PMID:8288031
Abstract
  1. A search for nucleoside phosphotransferase activity in Bacillus cereus led to the following results: (i) The phosphotransferase activity was associated with a membrane bound 5'-nucleotidase. (ii) The enzyme phosphorylates both purine and pyrimidine nucleosides as well as 2',3'-dideoxyinosine. (iii) The enzyme was inhibited by adenylic nucleotide di- and triphosphates, and its nucleotidase activity was increased in the presence of inosine as phosphate acceptor. 2. Bacterial and vertebrate 5'-nucleotidases with phosphotransferase activity differ for several characteristics, such as cellular location, substrate specificity, magnesium requirement and regulation.
摘要
  1. 对蜡样芽孢杆菌核苷磷酸转移酶活性的研究得出了以下结果:(i)磷酸转移酶活性与一种膜结合的5'-核苷酸酶相关。(ii)该酶可使嘌呤和嘧啶核苷以及2',3'-双脱氧肌苷磷酸化。(iii)该酶受到腺苷酸二磷酸和三磷酸的抑制,并且在肌苷作为磷酸受体存在时其核苷酸酶活性增强。2. 具有磷酸转移酶活性的细菌和脊椎动物5'-核苷酸酶在几个特征方面存在差异,例如细胞定位、底物特异性、镁需求和调节。

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1
Membrane-bound 5'-nucleotidase/nucleoside phosphotransferase from Bacillus cereus.蜡样芽孢杆菌的膜结合5'-核苷酸酶/核苷磷酸转移酶
Int J Biochem. 1993 Nov;25(11):1625-9. doi: 10.1016/0020-711x(93)90521-f.
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The bifunctional cytosolic 5'-nucleotidase: regulation of the phosphotransferase and nucleotidase activities.双功能胞质5'-核苷酸酶:磷酸转移酶和核苷酸酶活性的调节
Arch Biochem Biophys. 1994 Jul;312(1):75-80. doi: 10.1006/abbi.1994.1282.
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The phosphotransferase activity of cytosolic 5'-nucleotidase; a purine analog phosphorylating enzyme.胞质5'-核苷酸酶的磷酸转移酶活性;一种嘌呤类似物磷酸化酶。
Int J Biochem Cell Biol. 1996;28(6):711-20. doi: 10.1016/1357-2725(95)00171-9.
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Nucleoside phosphotransferase activity of human colon carcinoma cytosolic 5'-nucleotidase.人结肠癌胞质5'-核苷酸酶的核苷磷酸转移酶活性
Arch Biochem Biophys. 1991 Dec;291(2):212-7. doi: 10.1016/0003-9861(91)90125-3.
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Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart.核苷酸和核苷类似物作为心脏胞质5'-核苷酸酶I的抑制剂
Biochemistry. 1998 Jun 23;37(25):9043-51. doi: 10.1021/bi980209d.
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Cytosolic 5'-nucleotidase/nucleoside phosphotransferase: a nucleoside analog activating enzyme?胞质5'-核苷酸酶/核苷磷酸转移酶:一种核苷类似物激活酶?
J Biochem Toxicol. 1994 Feb;9(1):51-7. doi: 10.1002/jbt.2570090108.
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Mechanisms of exogenous purine nucleotide utilization in Bacillus cereus.
Curr Top Cell Regul. 1985;26:419-32. doi: 10.1016/b978-0-12-152826-3.50040-1.
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Induction and repression of enzymes involved in exogenous purine compound utilization of Bacillus cereus.蜡样芽孢杆菌中外源嘌呤化合物利用相关酶的诱导与抑制
Biochim Biophys Acta. 1981 Dec 18;678(3):460-6. doi: 10.1016/0304-4165(81)90127-6.
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Membrane-bound nucleotidase of Bacillus cereus.蜡样芽孢杆菌的膜结合核苷酸酶。
J Bacteriol. 1978 Feb;133(2):576-83. doi: 10.1128/jb.133.2.576-583.1978.
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Mechanism of the reaction catalysed by cytosolic 5'-nucleotidase/phosphotransferase: formation of a phosphorylated intermediate.胞质5'-核苷酸酶/磷酸转移酶催化的反应机制:磷酸化中间体的形成。
Biochem J. 1996 Aug 1;317 ( Pt 3)(Pt 3):797-801. doi: 10.1042/bj3170797.

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