Melluish J W, Brooks C D, Ruoff G, Cross C J, Sanborn E C
Arch Ophthalmol. 1975 Sep;93(9):781-2. doi: 10.1001/archopht.1975.01010020675003.
Eye evaluations before and after 24 weeks of treatment with either ibuprofen (Motrin) or aspirin did not show eye toxicity with either drug in a double-blind study of 78 patients with osteoarthritis. The possibility of eye complications resulting from ibuprofen therapy suggested in two earlier reports has not been confirmed in clinical usage in other countries or in clinical trials in the United States.
在一项针对78名骨关节炎患者的双盲研究中,使用布洛芬(Motrin)或阿司匹林治疗24周前后的眼部评估显示,这两种药物均未表现出眼部毒性。之前两份报告中所提及的布洛芬治疗引发眼部并发症的可能性,在其他国家的临床应用或美国的临床试验中均未得到证实。