Repeat trials of oocyte donation to women with previous donor oocyte success.

Oocyte donation has proven to be highly successful in establishing pregnancy in functionally agonadal women. Both implantation and ongoing pregnancy rates in women using this method have surpassed those normally seen in standard in-vitro fertilization (IVF) patients. Over a 5 year period, seven women who had previously conceived using oocyte donation elected to attempt pregnancy and deliver a second child using the same donor. In each case the paramount consideration was to provide a sibling of the same genetic make-up as the child or children previously borne. Of the seven women studied, whose ages ranged from 24 to 44 years, five became pregnant on subsequent cycles. The time to conception varied from one to a maximum of three attempts with three of the five women becoming pregnant on the first cycle and two requiring three cycles to establish the subsequent pregnancy. The overall rate of success in this group was 12 pregnancies in 20 cycles of embryo transfer (60%). An exaggerated implantation rate (25.6%) was also noted (23 individual embryo implantations from 90 embryos transferred). Of the 12 pregnancies established in these seven women, four (33%) were multiple gestations (three triplets, one twin). We conclude that women who have previously experienced pregnancy following oocyte donation are highly likely to conceive in a subsequent trial at a rate that may be higher than that normally seen in the general population of women undergoing oocyte donation.