Jiaxiang N, Fujii K, Sato N, Yuge O
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Hiroshima University, Japan.
J Appl Toxicol. 1993 Nov-Dec;13(6):385-8. doi: 10.1002/jat.2550130604.
The effect of Gomisi (dried ripe fruit of schizandra chinensis) on chlorodifluoroethylene (CDE) and chlorotrifluoroethane (CTE) formation was investigated. The incubation mixtures for the measurement of reductive metabolites of halothane consisted of liver microsomal suspensions, 3 mM NADPH, extract solution of Gomisi and halothane in 0.1 M potassium phosphate buffer (pH 7.4). The production of CDE and CTE was inhibited by Gomisi in a dose-dependent way. The production were reduced to half in the presence of 0.5% Gomisi extract in the reaction mixture. The results suggest that Gomisi can inhibit the reductive metabolism of halothane in vitro; thus it may protect against halothane-induced hepatitis.
研究了五味子（五味子干燥成熟果实）对二氯二氟乙烯（CDE）和三氯氟乙烷（CTE）形成的影响。用于测量氟烷还原代谢产物的孵育混合物由肝微粒体悬浮液、3 mM烟酰胺腺嘌呤二核苷酸磷酸（NADPH）、五味子提取物溶液以及氟烷组成，置于0.1 M磷酸钾缓冲液（pH 7.4）中。五味子以剂量依赖的方式抑制CDE和CTE的产生。在反应混合物中存在0.5%五味子提取物的情况下，产量降低至一半。结果表明，五味子在体外可抑制氟烷的还原代谢；因此它可能预防氟烷诱导的肝炎。
