Hufford C D, Jia Y, Croom E M, Muhammed I, Okunade A L, Clark A M, Rogers R D
Department of Pharmacognosy, University of Mississippi, University 38677.
J Nat Prod. 1993 Nov;56(11):1878-89. doi: 10.1021/np50101a003.
EtOH extracts of Petalostemum purpureum demonstrated antimicrobial activity against bacteria and fungi. Bioassay-directed fractionation led to the isolation of petalostemumol [1] as the active constituent. Its structure was determined by a single crystal X-ray diffraction analysis. A minor component designated petalostemumol G [3] is believed to be an artifact of the isolation procedure. Its structure was confirmed by a single crystal X-ray analysis of its pentamethylether 2. A number of derivatives of 1 and 3, including the Me- and benzylethers and acetates, were prepared.
紫茎泽兰乙醇提取物对细菌和真菌具有抗菌活性。通过生物活性导向的分级分离，分离出了紫茎泽兰醇[1]作为活性成分。其结构通过单晶X射线衍射分析确定。一种名为紫茎泽兰醇G[3]的次要成分被认为是分离过程中的假象。它的五甲基醚2的单晶X射线分析证实了其结构。制备了1和3的多种衍生物，包括甲基醚和苄基醚以及乙酸酯。
