Vargas F, Canudas N, Miranda M A, Boscá F
Centro de Química, Instituto Venezolano de Investigaciones Científicas IVIC, Caracas.
J Photochem Photobiol B. 1993 Nov;21(1):61-7. doi: 10.1016/1011-1344(93)80165-6.
Aqueous or methanolic solutions of clofibrate and clofibric acid are photolabile towards UVB light under aerobic as well as anaerobic conditions. Nine photoproducts have been identified; their formation involves primary cleavage of the carbon-halogen bond or of the aryloxy-carbon bond, followed by hydrogen abstraction and/or radical recombination. Clofibric acid is phototoxic in vitro as indicated by the photohemolysis test, under both oxygen and argon atmospheres, although the photohemolysis rate is markedly higher under aerobic conditions. Partial inhibition of this process on addition of butylated hydroxyanisole (BHA), reduced glutathione (GSH), sodium azide (NaN3) or 1,4-diazabicyclo[2.2.2]octane (DABCO) suggests the involvement of type I as well as type II mechanisms.
在有氧和无氧条件下，氯贝丁酯和氯贝酸的水溶液或甲醇溶液对中波紫外线（UVB）光不稳定。已鉴定出九种光产物；它们的形成涉及碳-卤键或芳氧基-碳键的初级裂解，随后是氢的夺取和/或自由基重组。光溶血试验表明，在氧气和氩气气氛下，氯贝酸在体外具有光毒性，尽管在有氧条件下光溶血率明显更高。添加丁基化羟基茴香醚（BHA）、还原型谷胱甘肽（GSH）、叠氮化钠（NaN3）或1,4-二氮杂双环[2.2.2]辛烷（DABCO）对该过程的部分抑制表明涉及I型和II型机制。
