一例经原位杂交定位的费城染色体阴性、M-BCR重排的8三体嗜酸性粒细胞白血病病例。
A case of Philadelphia-negative, M-BCR rearranged eosinophilic leukaemia with trisomy 8 localized by in situ hybridization.
作者信息
Chan L C, Kwong Y L, Lie A K, Ching L M
机构信息
Department of Pathology, University of Hong Kong.
出版信息
Leukemia. 1994 Jan;8(1):195-8.
PMID:8289488
Abstract
A case of Ph-negative M-BCR rearranged eosinophilic leukaemia with clonal cytogenetic abnormalities is presented. In addition to involvement of the short arm of chromosome 12 (12p12?13), the malignant nature of the eosinophils was confirmed by the demonstration of trisomy 8 by in situ hybridization.
摘要
本文报告1例Ph阴性、M-BCR重排且伴有克隆性细胞遗传学异常的嗜酸性粒细胞白血病。除12号染色体短臂（12p12？13）受累外，原位杂交显示8号染色体三体进一步证实了嗜酸性粒细胞的恶性性质。
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