Kastenbauer E R, Hochstrasser K
Laryngol Rhinol Otol (Stuttg). 1978 Oct;57(10):869-71.
Among the three investigated proteinase inhibitors alpha-1-antitrypsin ("acute phase protein") possesses the highest antiproteolytic capacity. Alpha-2-macroglobulin reaches as an average one fifth of the preoperative level of alpha-1-antitrypsin and postoperatively one quater of this inhibitor level. The average concentrations of the low molecular acid stable proteinase inhibitor of the mucous membrane in the preoperative phase are about equivalent to the concentrations of alpha-2-macroglobulin. In the postoperative phase the concentrations of the low molecular acid stable inhibitor are a slightly lower than those of alpha-2-macroglobulin. The samples of the middle ear secretions from cases with chronic otitis media or with cholesteatoma do not differ essentially in their concentrations of the different proteinase inhibitors.
在所研究的三种蛋白酶抑制剂中，α-1抗胰蛋白酶（“急性期蛋白”）具有最高的抗蛋白水解能力。α-2巨球蛋白平均达到术前α-1抗胰蛋白酶水平的五分之一，术后达到该抑制剂水平的四分之一。术前阶段黏膜低分子酸稳定蛋白酶抑制剂的平均浓度约与α-2巨球蛋白的浓度相当。术后阶段，低分子酸稳定抑制剂的浓度略低于α-2巨球蛋白的浓度。慢性中耳炎或胆脂瘤病例的中耳分泌物样本中，不同蛋白酶抑制剂的浓度基本没有差异。
