Grimston S K
Human Performance Laboratory, Faculty of Physical Education, University of Calgary, Alberta, Canada.
Med Sci Sports Exerc. 1993 Nov;25(11):1293-7.
In this paper a theoretical model for research into the area of bone health is proposed. The model is based on the mechanostat theory of bone biology, originally proposed by Harold M. Frost, and is directed toward research in the area of osteoporosis. The mechanostat theory is briefly reviewed, including the concept of changes in minimum effective strain thresholds. Each of the model's five levels is then detailed, followed by discussion of their application to research design and interpretation. The proposed research model may provide a systematic approach to research design, and thereby a method to increase the current understanding of bone biology.
本文提出了一个用于骨骼健康领域研究的理论模型。该模型基于哈罗德·M·弗罗斯特最初提出的骨骼生物学的机械稳态理论，旨在骨质疏松症领域的研究。文中简要回顾了机械稳态理论，包括最小有效应变阈值变化的概念。接着详细阐述了该模型的五个层次，随后讨论了它们在研究设计和解释中的应用。所提出的研究模型可为研究设计提供一种系统方法，从而增加目前对骨骼生物学的理解。
