van den Berg A A, Honjol N M
Department of Anaesthesia, Riyad Armed Forces Hospital, Kingdom of Saudi Arabia.
Middle East J Anaesthesiol. 1993 Oct;12(3):271-86.
A prospective study was undertaken on 169 healthy young patients undergoing elective ear, nose and throat surgery to assess the intraoperative effects on heart rate, blood pressure and bronchomotor tone of MAC in nitrous oxide concentrations of halothane (0.4 to 0.6%), isoflurane (0.6 to 0.8%) and enflurane (0.8 to 1%). All the agents produced a progressive slowing of the heart rate during anesthesia. Halothane did so most profoundly, resulting in a maximum slowing of 40 beats-1 compared with a maximum slowing of about 20 beats min-1 with both isoflurane and enflurane. The three volatile agents also produced progressively similar degrees of hypotension during anesthesia. The hypotension produced by enflurane occurred earliest and was most profound; that produced by isoflurane occurred less early and was less severe, but occurred earlier and was more severe than that produced by halothane. Neither halothane, isoflurane nor enflurane appeared to have any effect on bronchomotor tone.
对169例接受择期耳鼻喉手术的健康年轻患者进行了一项前瞻性研究，以评估在氧化亚氮中，氟烷（0.4%至0.6%）、异氟烷（0.6%至0.8%）和恩氟烷（0.8%至1%）的MAC对心率、血压和支气管运动张力的术中影响。所有药物在麻醉期间均使心率逐渐减慢。氟烷的这种作用最为显著，导致最大减慢幅度为40次/分钟，而异氟烷和恩氟烷的最大减慢幅度约为20次/分钟。这三种挥发性药物在麻醉期间也产生了逐渐相似程度的低血压。恩氟烷引起的低血压出现最早且最严重；异氟烷引起的低血压出现较晚且程度较轻，但比氟烷引起的低血压出现更早且更严重。氟烷、异氟烷和恩氟烷似乎对支气管运动张力均无任何影响。
