Yamamoto T, Horiguchi H, Shibagaki T, Kamma H, Ogata T, Mitsui K
Department of Thoracic Surgery, University of Tsukuba, Ibaraki, Japan.
Respiration. 1993;60(6):373-7. doi: 10.1159/000196238.
An unusual benign lung neoplasm, a papillary adenoma of type II pneumocytes, was resected from a 26-year-old man who showed no clinical symptoms. The tumor was 2.0 cm in diameter and was localized in the subpleural region of S7 of the right lung; the cut surface showed a spherical medullary mass encapsulated by a thin layer of connective tissue. Histologically, there were cuboidal to columnar epithelial cells with a little nuclear atypia showing a monotonous papillary pattern with a delicate stroma in most parts of the tumor. There was neither capsular invasion nor metastasis of tumor cells. Nuclear DNA analysis of the tumor cells showed a diploid pattern and a low S-phase fraction. The immunohistochemical study revealed that most tumor cells contained a large amount of surfactant apoprotein in the cytoplasm. Osmiophilic lamellar bodies characteristic of type II pneumocytes were frequently found by electron microscopy. These findings indicate that this was a benign adenoma of the lung arising from type II pneumocytes.
从一名无临床症状的26岁男性患者身上切除了一种不寻常的良性肺肿瘤——II型肺上皮细胞乳头状腺瘤。肿瘤直径为2.0 cm，位于右肺S7的胸膜下区域；切面显示为一个球形髓质肿块，被一层薄结缔组织包裹。组织学上，肿瘤大部分区域有立方形至柱状上皮细胞，有少许核异型性，呈单调的乳头状结构，伴有纤细的间质。未见肿瘤细胞包膜侵犯及转移。肿瘤细胞核DNA分析显示为二倍体模式，S期分数较低。免疫组化研究显示，大多数肿瘤细胞的细胞质中含有大量表面活性物质载脂蛋白。通过电子显微镜经常发现具有II型肺上皮细胞特征的嗜锇板层小体。这些发现表明这是一例起源于II型肺上皮细胞的肺良性腺瘤。
