Dean R T, Gieseg S, Davies M J
Cell Biology Group, Heart Research Institute, Sydney, NSW, Australia.
Trends Biochem Sci. 1993 Nov;18(11):437-41. doi: 10.1016/0968-0004(93)90145-d.
Hydroperoxides and catechols are described as novel reactive products of radical attack on proteins. These species, like other components of oxidized and otherwise damaged proteins, may accumulate in some biological systems. We propose that the reactive species may then attack other biomolecules, and constitute both a marker and a mechanism of age-related pathologies.
氢过氧化物和儿茶酚被描述为自由基攻击蛋白质产生的新型反应产物。这些物质，与氧化及其他受损蛋白质的其他成分一样，可能在某些生物系统中积累。我们提出，这些反应性物质随后可能会攻击其他生物分子，并构成与年龄相关病理的标志物和机制。
