Matsuoka Y, Nishikawa M, Toyoda H, Hirokawa Y, Ando S, Yano T, Tanabe K, Yatani R
Department of Pathology, Mie University School of Medicine, Japan.
Biochem Biophys Res Commun. 1994 Jan 14;198(1):111-9. doi: 10.1006/bbrc.1994.1016.
Spectrin and protein 4.1 became associated with the Triton-insoluble cytoskeletons during platelet activation. Inhibition of platelet activation by a PGI2 analogue resulted in release of the proteins from the cytoskeletons. Changes in subcellular distributions of the proteins preceded changes in the state of platelet aggregation. These results suggest that interactions of spectrin and protein 4.1 with the cytoskeletons are involved in mediating the physiological response of the platelet.
在血小板活化过程中，血影蛋白和蛋白4.1与不溶于曲通X-100的细胞骨架结合。前列环素类似物对血小板活化的抑制导致这些蛋白从细胞骨架中释放出来。这些蛋白亚细胞分布的变化先于血小板聚集状态的变化。这些结果表明，血影蛋白和蛋白4.1与细胞骨架的相互作用参与介导血小板的生理反应。
