Severina I S
Biokhimiia. 1976 Jul;41(6):955-67.
Problems on multiple forms of mitochondrial monoamine oxidases are considered. Possible nature of monoamine oxidase isoenzymes and its A and B forms is discussed. Substrates specificity of mitochondrial monoamine oxidase and the importance of amine chemical structure for the enzyme activity is examined. The data on the structure of mitochondrial monoamine oxidase active center and the presence in it of several regions responsible for amine binding are analyzed. The nature of these regions is discussed. New approaches to selective blocking of the activity of mitochondrial monoamine oxidase are considered on the basis of the hypothesis given on the mechanism of substrate and inhibitor interaction with the enzyme.
本文探讨了线粒体单胺氧化酶多种形式的相关问题。讨论了单胺氧化酶同工酶及其A和B形式的可能性质。研究了线粒体单胺氧化酶的底物特异性以及胺类化学结构对酶活性的重要性。分析了线粒体单胺氧化酶活性中心的结构数据以及其中负责胺类结合的几个区域的存在情况。讨论了这些区域的性质。基于底物和抑制剂与酶相互作用机制的假设，考虑了选择性阻断线粒体单胺氧化酶活性的新方法。
