Ackermann M, Kirchner H, Atzpodien J
Division of Hematology and Oncology, Medizinische Hochschule Hannover, Germany.
Anticancer Drugs. 1993 Oct;4(5):585-7. doi: 10.1097/00001813-199310000-00009.
The progression of advanced malignancies is often associated with anorexia and cachexia, especially when patients receive concomitant systemic antitumor treatment. Megestrol acetate has been reported to increase appetite and body weight, and a linear dose-response relation for doses from 160 up to 1600 mg/day has been proposed. In our study, we were able to show that megestrol acetate at doses as low as 60 mg/day was sufficient to abrogate anorexia and weight loss. In contrast to previous studies, this effect was achieved while patients continued systemic antineoplastic therapy.
晚期恶性肿瘤的进展通常与厌食和恶病质有关，尤其是当患者同时接受全身抗肿瘤治疗时。据报道，醋酸甲地孕酮可增加食欲和体重，并且有人提出了160至1600毫克/天剂量的线性剂量反应关系。在我们的研究中，我们能够证明，低至60毫克/天的醋酸甲地孕酮剂量足以消除厌食和体重减轻。与先前的研究不同，这种效果是在患者继续进行全身抗肿瘤治疗时实现的。
