[Acute effects of hemodialysis on circulating parathormone, osteocalcin and alkaline phosphatase in patients with chronic renal failure].

The authors investigated biochemical indicators of the phosphocalcium metabolism in 18 patients dialyzed for prolonged periods on account of chronic renal failure before and after 5-hour dialysis. During dialysis serum creatinine and phosphorus levels declined and serum calcium levels rose. The level of immunoreactive parathyroid hormone (C-terminal), total alkaline phosphatase and gamma-glutamyl transferase did not change. During five hours of dialysis, as compared with alkaline phosphatase, mainly its bone isoenzyme, a marked increase of osteocalcin, an index of de novo bone formation, was recorded. From the investigation it is obvious that osteocalcin with a half-life of 5 minutes is an index of acute changes of the bone metabolism and its rise during dialysis indicates the favourable effect of dialysis on osteoblast activity.