Henion P D, Weston J A
Institute of Neuroscience, University of Oregon, Eugene 97403.
Dev Biol. 1994 Jan;161(1):243-50. doi: 10.1006/dbio.1994.1024.
The neural crest produces both neuronal and nonneuronal derivatives in response to a variety of environmental cues. Here, we have analyzed the effects of retinoic acid on the differentiative behavior of quail trunk neural crest cells in vitro. We show that retinoic acid selectively increases neurogenesis in cultured neural crest cell populations, probably by promoting the survival and stimulating the proliferation of neuronal precursors. Our results suggest that neural crest-derived neurogenic precursors are specific targets for retinoic acid in vitro and raise the possibility that retinoic acid promotes the generation of peripheral neurons in vivo.
神经嵴在多种环境信号的作用下产生神经元和非神经元衍生物。在此，我们分析了视黄酸对体外培养的鹌鹑躯干神经嵴细胞分化行为的影响。我们发现视黄酸可选择性地增加培养的神经嵴细胞群体中的神经发生，这可能是通过促进神经元前体细胞的存活和刺激其增殖来实现的。我们的结果表明，神经嵴衍生的神经源性前体细胞是体外视黄酸的特定作用靶点，并提出了视黄酸在体内促进外周神经元生成的可能性。
