Rohde A, Marneros A
Universitäts-Nervenklinik Bonn.
Geburtshilfe Frauenheilkd. 1993 Nov;53(11):800-10. doi: 10.1055/s-2007-1023730.
86 women who suffered from a psychotic disorder for the first time in their life within 6 weeks after parturition, were investigated regarding sociodemographic and gynaecological parameters, time of onset and initial symptomatology, psychopathological symptoms during hospitalisation, treatment and short-term outcome of the illness. The majority of patients became ill after the first (75%), full-term normal (63%) delivery and within the first two postpartum weeks (78%). The most frequent initial symptoms were anxiety, restlessness, depressive mood, sleep disturbances, behaviour disturbances, catatonic excitement, delusions and hallucinations. By the time of follow-up investigation, 16 women had died; 61 women were investigated on average 25.6 years after onset (minimum 12, maximum 41 years), using standardised instruments of evaluation. Nearly two-thirds of the patients had suffered re-manifestation of psychotic disorder during a long-term course (64%). The frequency of re-manifestations of illness after additional pregnancies and deliveries was found to be 1:4, which is also known to be the expected frequency during the course of other psychotic disorders. These results do not justify the global recommendation to avoid additional pregnancies or carry out an interruption of pregnancy, if the patient has a history of postpartum psychosis. The climacteric period also seems to be a vulnerable phase for the re-manifestation of illness. Nearly 3/4 of the investigated women displayed no disturbances in any of the evaluated dimensions (psychopathological, psychological, psychosocial status) at the time of follow-up.
86名在产后6周内首次出现精神障碍的女性,接受了关于社会人口学和妇科参数、发病时间和初始症状、住院期间的精神病理症状、疾病治疗及短期转归的调查。大多数患者在首次(75%)、足月顺产(63%)后发病,且在产后头两周内(78%)。最常见的初始症状为焦虑、烦躁不安、抑郁情绪、睡眠障碍、行为紊乱、紧张性兴奋、妄想和幻觉。在随访调查时,16名女性已死亡;61名女性在发病后平均25.6年(最短12年,最长41年)接受调查,采用标准化评估工具。近三分之二的患者在病程中出现过精神障碍复发(64%)。发现再次怀孕和分娩后疾病复发的频率为1:4,这也是其他精神障碍病程中已知的预期频率。如果患者有产后精神病病史,这些结果并不足以支持全面建议避免再次怀孕或终止妊娠。绝经期似乎也是疾病复发的一个脆弱阶段。近四分之三接受调查的女性在随访时,在任何评估维度(精神病理、心理、社会心理状态)均未显示出障碍。