Vivaldi P, Savino M, Mazzon C, Rubertelli M
Geriatrics Department, Santa Chiara General Hospital, Trento, Italy.
Haematologica. 1993 Jul-Aug;78(4):245-8.
We report here 2 cases of elderly patients who were admitted to our Department of Geriatrics for a hemorrhagic syndrome. The patients were found to be affected by a coagulopathy with prolonged activated partial thromboplastin time (aPTT), caused by the presence of an acquired inhibitor of Factor VIII. This syndrome, due to anti-Factor VIII antibodies, is surely an important clinical entity that is not easy to diagnosed, but in concomitance with a hemorrhagic syndrome and prolonged aPPT it should always be suspected. In fact, a quick diagnosis is very important in order to apply specific treatment as soon as possible.
我们在此报告2例老年患者，他们因出血综合征入住我院老年医学科。患者被发现患有凝血障碍，活化部分凝血活酶时间（aPTT）延长，这是由获得性VIII因子抑制剂的存在引起的。由于抗VIII因子抗体导致的这种综合征，无疑是一种重要的临床病症，不易诊断，但在伴有出血综合征和aPPT延长时应始终予以怀疑。事实上，快速诊断对于尽快应用特异性治疗非常重要。
