Maikowski C, Rösch W, Sörgel F
Medizinische Klinik, Stiftung Hospital zum Heiligen Geist, Frankfurt/M.
Fortschr Med. 1993 Nov 20;111(32):513-6.
In 12 patients with inoperable malignant obstructive jaundice, percutaneous transhepatic biliary drainage was performed to decompensate the bile ducts. For a period of 7 days, the patients received a single daily i.v. dose of 1 g CFTX, and the serum and bile concentrations were measured at defined intervals.
The dose sufficed to kill about 85% of the expected organisms. Although an accumulation of the substance as documented under conditions of normal bile flow was not demonstrable under cholestatic conditions, effective levels were nevertheless found in the bile and showed a tendency to increase with increasing bile flow.
对12例无法手术的恶性梗阻性黄疸患者行经皮经肝胆道引流以解除胆管梗阻。在7天的时间里，患者每天静脉注射1克头孢噻肟，在规定的时间间隔测量血清和胆汁浓度。
该剂量足以杀灭约85%的预期细菌。虽然在胆汁淤积情况下未发现正常胆汁流动条件下所记录的物质蓄积，但在胆汁中仍发现有效浓度，且有随胆汁流量增加而升高的趋势。
