Göbel H, Krapat S, Ensink F B, Soyka D
Department of Neurology, University of Kiel, Germany.
Headache. 1993 Nov-Dec;33(10):570-2. doi: 10.1111/j.1526-4610.1993.hed3310570.x.
We compared in a placebo controlled, double blind, crossover within-subject design, the amplitude and area integral of contingent negative variation (CNV) using a 2 second interstimulus interval in migraine patients between attack and interval before and after treatment. The study was conducted on 14 female subjects suffering from migraine without aura. The measurements were performed in a balanced sequence at four different times on each patient, twice during the migraine interval and once in each of two migraine attacks. The CNV in the patients was measured first (baseline), then medication was administered on a double-blind basis with an autoinjector, using either 6 mg sumatriptan or a placebo solution. Thirty minutes after administration the CNV parameters were measured again and the changes between pre- and post-treatment were taken as dependent variables. CNV amplitude baseline readings did not differ significantly between the four conditions. Neither administration of placebo nor sumatriptan led to a significant change in CNV parameters independent of whether significant clinical improvement of migraine headache occurred or not. According to our findings CNV-mechanisms between attack and interval are not subject to short-term changes, even though a small, not significant tendency towards a decrease in CNV amplitude during migraine attacks appears to exist. Therefore, it can be assumed that changes in the systems which are depicted by CNV readings are not involved in initiating and terminating acute migraine attacks.
我们采用安慰剂对照、双盲、受试者内交叉设计，比较了偏头痛患者发作期与发作间期以及治疗前后，在2秒刺激间隔下的关联性负变（CNV）的幅度和面积积分。该研究对14名无先兆偏头痛女性受试者进行。测量在每个患者的四个不同时间以平衡顺序进行，在偏头痛间期进行两次，在两次偏头痛发作中各进行一次。首先测量患者的CNV（基线），然后使用自动注射器以双盲方式给药，使用6毫克舒马曲坦或安慰剂溶液。给药30分钟后再次测量CNV参数，并将治疗前后的变化作为因变量。在四种情况下，CNV幅度的基线读数无显著差异。无论偏头痛头痛是否有显著临床改善，给予安慰剂或舒马曲坦均未导致CNV参数发生显著变化。根据我们的研究结果，尽管在偏头痛发作期间CNV幅度似乎有轻微的、不显著的下降趋势，但发作期与发作间期之间的CNV机制不受短期变化影响。因此，可以假设由CNV读数所描绘的系统变化不参与急性偏头痛发作的起始和终止。
