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J Cell Biol. 1994 Feb;124(3):273-87. doi: 10.1083/jcb.124.3.273.
2
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Cell. 1991 Feb 22;64(4):789-800. doi: 10.1016/0092-8674(91)90508-v.
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Essential role for diacylglycerol in protein transport from the yeast Golgi complex.二酰基甘油在酵母高尔基体复合体蛋白质转运中的重要作用。
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本文引用的文献

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SACCHAROMYCES CEREVISIAE Recessive Suppressor That Circumvents Phosphatidylserine Deficiency.酿酒酵母的隐性抑制子可绕过磷脂酰丝氨酸缺乏。
Genetics. 1984 Nov;108(3):533-43. doi: 10.1093/genetics/108.3.533.
2
Interpreting the effects of blocking PC biosynthesis.解读阻断磷脂酰胆碱生物合成的效果。
Trends Cell Biol. 1992 Mar;2(3):71; discussion 71-2. doi: 10.1016/0962-8924(92)90062-r.
3
Phospholipid transfer proteins: a biological debut.磷脂转运蛋白：生物学领域的首次亮相。
Trends Cell Biol. 1991 Jul;1(1):30-4. doi: 10.1016/0962-8924(91)90067-j.
4
SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast.SAC1p是一种整合膜蛋白，它影响酵母中磷脂转移蛋白功能和肌醇的细胞需求。
J Cell Biol. 1993 Jul;122(1):79-94. doi: 10.1083/jcb.122.1.79.
5
Phospholipid transfer activity is relevant to but not sufficient for the essential function of the yeast SEC14 gene product.磷脂转移活性与酵母SEC14基因产物的基本功能相关，但并不足以实现该功能。
EMBO J. 1993 Dec;12(12):4775-84. doi: 10.1002/j.1460-2075.1993.tb06166.x.
6
Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol-excreting mutants.酵母中肌醇生物合成的调控突变：肌醇分泌突变体的分离
Genetics. 1982 Jan;100(1):19-33. doi: 10.1093/genetics/100.1.19.
7
Yeast mutant defective in phosphatidylserine synthesis.磷脂酰丝氨酸合成缺陷的酵母突变体。
J Biol Chem. 1980 Jul 25;255(14):6653-61.
8
Selective release of content from microsomal vesicles without membrane disassembly. I. Permeability changes induced by low detergent concentrations.在不破坏膜结构的情况下从微粒体囊泡中选择性释放内容物。I. 低去污剂浓度诱导的通透性变化。
J Cell Biol. 1973 Aug;58(2):436-62. doi: 10.1083/jcb.58.2.436.
9
Cytochrome c oxidase from bakers' yeast. I. Isolation and properties.来自面包酵母的细胞色素c氧化酶。I. 分离与性质
J Biol Chem. 1973 Feb 25;248(4):1346-54.
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In vitro studies of phospholipid biosynthesis in Saccharomyces cerevisiae.酿酒酵母中磷脂生物合成的体外研究。
Biochim Biophys Acta. 1972 Feb 21;260(2):222-43. doi: 10.1016/0005-2760(72)90035-5.

一种磷脂酰肌醇转移蛋白控制酵母高尔基体膜的磷脂酰胆碱含量。

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes.

作者信息

McGee T P, Skinner H B, Whitters E A, Henry S A, Bankaitis V A

机构信息

Department of Cell Biology, University of Alabama at Birmingham 35294-0005.

出版信息

J Cell Biol. 1994 Feb;124(3):273-87. doi: 10.1083/jcb.124.3.273.

DOI:10.1083/jcb.124.3.273
PMID:8294512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2119930/
Abstract

SEC14p is required for protein transport from the yeast Golgi complex. We describe a quantitative analysis of yeast bulk membrane and Golgi membrane phospholipid composition under conditions where Golgi secretory function has been uncoupled from its usual SEC14p requirement. The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained.

摘要

SEC14p是酵母高尔基体复合体进行蛋白质转运所必需的。我们描述了在高尔基体分泌功能与其通常对SEC14p的需求脱钩的条件下，对酵母整体膜和高尔基体膜磷脂组成的定量分析。数据表明，SEC14p的特定功能是维持高尔基体膜中磷脂酰胆碱含量的降低，并表明SEC14p的过量表达显著降低了体内通过CDP-胆碱途径合成磷脂酰胆碱的表观速率。我们认为，SEC14p作为高尔基体膜磷脂组成的传感器，通过它调节高尔基体膜中CDP-胆碱途径的活性，从而维持与这些膜的基本分泌功能相适应的磷脂酰胆碱含量。