酿酒酵母的隐性抑制子可绕过磷脂酰丝氨酸缺乏。
SACCHAROMYCES CEREVISIAE Recessive Suppressor That Circumvents Phosphatidylserine Deficiency.
机构信息
Department of Biology, University of California, Riverside, California 92521.
出版信息
Genetics. 1984 Nov;108(3):533-43. doi: 10.1093/genetics/108.3.533.
Abstract
Phenotypic reversion of six independent Saccharomyces cerevisiae cho1 mutants was shown to be due predominantly to mutation of an unlinked gene, eam1. The eam1 gene was located very close to ino1 on chromosome X by meiotic tetrad analysis. Recessive eam1 mutations did not correct the primary cho1 defect in phosphatidylserine synthesis but made endogenous ethanolamine available for sustained nitrogenous phospholipid synthesis. A novel biochemical contribution to nitrogenous lipid synthesis is indicated by the eam1 mutants.
摘要
表型回复的六个独立的酿酒酵母 cho1 突变体被证明主要是由于一个不相关的基因的突变，eam1。通过减数分裂四分体分析，eam1 基因位于染色体 X 上的 ino1 附近。隐性 eam1 突变不能纠正磷脂酰丝氨酸合成中的 cho1 主要缺陷，但使内源性乙醇胺可用于持续的含氮磷脂合成。eam1 突变体表明了对含氮脂质合成的一种新的生化贡献。
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