Goddu S M, Howell R W, Rao D V
Department of Radiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
J Nucl Med. 1994 Feb;35(2):303-16.
The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized.
Experimental range-energy relations for electrons and alpha particles, along with derived geometric reduction factors, are used to calculate cellular absorbed fractions for these radiations. The resulting absorbed fractions are employed to calculate cellular S-values for several radionuclides.
Cellular absorbed fractions for monoenergetic electron sources with energies ranging from 0.1 keV to 1 MeV, distributed uniformly in the source region, are calculated for several target<--source combinations including cell<--cell, cell<--cell surface, nucleus<--nucleus, nucleus<--cytoplasm and nucleus<--cell surface. Similar data are also provided for monoenergetic alpha particle sources with energies ranging from 3 to 10 MeV. S-values are also conveniently tabulated for 32P, 35S, 86Rb, 89Sr, 90Y, 91Y, 114mIn, 131I. Auger-electron-emitters 51Cr, 67Ga, 99mTc, 111In, 123I, 125I, 201TI, 203Pb and the alpha emitter 210Po. In addition, S-values are given for radionuclides in the 212Pb decay series, including 212Pb, 212Bi and 212Po. Both absorbed fractions and S-values are supplied for a number of different size cells and cell nuclei.
With the absorbed fractions and S-values in hand, along with experimentally determined information on the biokinetics and subcellular distribution of the radionuclides, the cellular self-absorbed dose can be conveniently calculated.
细胞剂量学在诊断和治疗核医学中的重要性正日益得到认可。
利用电子和α粒子的实验射程-能量关系以及推导的几何缩减因子，计算这些辐射的细胞吸收分数。所得吸收分数用于计算几种放射性核素的细胞S值。
计算了能量范围从0.1 keV到1 MeV的单能电子源在源区域均匀分布时，针对几种靶-源组合（包括细胞-细胞、细胞-细胞表面、细胞核-细胞核、细胞核-细胞质和细胞核-细胞表面）的细胞吸收分数。还提供了能量范围从3到10 MeV的单能α粒子源的类似数据。还方便地列出了32P、35S、86Rb、89Sr、90Y、91Y、114mIn、131I、俄歇电子发射体51Cr、67Ga、99mTc、111In、123I、125I、201TI、203Pb以及α发射体210Po的S值。此外，还给出了212Pb衰变系列中放射性核素（包括212Pb、212Bi和212Po）的S值。给出了多种不同大小细胞和细胞核的吸收分数和S值。
有了吸收分数和S值，以及关于放射性核素生物动力学和亚细胞分布的实验确定信息，就可以方便地计算细胞的自吸收剂量。
