Kadam P P, Saksena S G, Jagtap S R, Pantavaidya S M
Dept. of Anaesthesiology, LTMMC and LTMG Hospital, Sion, Bombay, Maharashtra.
J Postgrad Med. 1993 Jan-Mar;39(1):26-8.
Thirty patients (ASA I or II) requiring spine surgery under general anesthesia were studied. To induce hypotension, halothane 0.5 to 2.5% (n = 15) or nitroglycerin infusion (1-2 micrograms/kg/min) (n = 15) was used. The parameters studied were blood pressure, blood loss, operating time and recovery score. The systolic blood pressure was maintained between 80-100 mmHg during surgery in both the groups. The blood loss with nitroglycerin was significantly less (202 +/- 114 ml) than halothane group (602 +/- 312 ml). All the patients were alert at the end of surgery in the nitroglycerin group (recovery score 9.8 +/- 0.76) as against the halothane group (7.98 +/- 0.9 p < 0.01). Tachycardia or tachyphylaxis was not observed with nitroglycerin. This study suggests that continuous intravenous infusion of nitroglycerin is effective and safe in reducing blood loss and operating time during spine surgery.
对30例（ASA I或II级）需要在全身麻醉下进行脊柱手术的患者进行了研究。为诱导低血压，使用了0.5%至2.5%的氟烷（n = 15）或静脉输注硝酸甘油（1 - 2微克/千克/分钟）（n = 15）。研究的参数包括血压、失血量、手术时间和恢复评分。两组患者在手术期间收缩压均维持在80 - 100 mmHg之间。硝酸甘油组的失血量（202±114毫升）明显少于氟烷组（602±312毫升）。与氟烷组（恢复评分为7.98±0.9，p < 0.01）相比，硝酸甘油组所有患者在手术结束时均清醒（恢复评分为9.8±0.76）。使用硝酸甘油未观察到心动过速或快速耐受性。该研究表明，在脊柱手术期间持续静脉输注硝酸甘油在减少失血量和手术时间方面是有效且安全的。
