Collins J N, Dyess D L, Ardell J L, Townsley M I, Taylor A E, Ferrara J J
University of South Alabama Department of Surgery, Mobile 36688.
J Trauma. 1994 Jan;36(1):27-33. doi: 10.1097/00005373-199401000-00005.
In a canine hind leg model, lymph flow (QL), lymph (CL), and plasma (CP) total protein concentrations, the reflection coefficient for total proteins (sigma d), and the filtration coefficient (Kf) were determined before and for 6 hours after a 5-second 100 degrees C hind paw scald (3% total body surface area, TBSA). Before injury, hind leg venous pressure was elevated and maintained by outflow restriction until a minimal, steady-state CL/CP ratio was achieved. Albumin (5%) was infused 30 minutes after the scald at low (0.4 mL/kg/% TBSA) or high (2 mL/kg/% TBSA) doses. Scald uniformly increased QL, CL/CP, Kf, and paw weight gain (PWG). Whereas postburn infusion of low-dose albumin mildly attenuated increases in CL/CP and PWG noted in scald-alone animals, no differences were noted between the scald and scald/high-dose albumin groups.
在犬后肢模型中，测定了5秒100℃后爪烫伤（3%体表面积，TBSA）前及烫伤后6小时的淋巴流量（QL）、淋巴（CL）和血浆（CP）总蛋白浓度、总蛋白的反射系数（σd）以及滤过系数（Kf）。在损伤前，通过限制流出使后肢静脉压升高并维持，直到达到最小稳态CL/CP比值。烫伤30分钟后，以低剂量（0.4 mL/kg/%TBSA）或高剂量（2 mL/kg/%TBSA）输注白蛋白（5%）。烫伤使QL、CL/CP、Kf和爪重量增加（PWG）均增加。虽然烫伤后低剂量白蛋白输注轻度减弱了单纯烫伤动物中CL/CP和PWG的增加，但烫伤组与烫伤/高剂量白蛋白组之间未观察到差异。
