Urase F, Ishikawa H, Kanbara M, Hazu S, Tsuji K, Ashida T, Tsubaki K, Horiuchi A
Third Department of Internal Medicine, Kinki University School of Medicine.
Rinsho Ketsueki. 1993 Dec;34(12):1584-6.
The results of unrelated bone marrow transplantation (BMT) is poor because of the rejection of bone marrow graft and graft versus host disease (GVHD). However, the rate of rejection has been reported to be decreased by intensive immuno-suppressive preconditioning regimens combined with total body irradiation (TBI). We report a case of an 18-year-old male with severe aplastic anemia who received a matched BMT from an unrelated donor. The pre-conditioning regimen included cyclophosphamide (50mg/kg) for 4 days, total lymphoid irradiation (TLI: 6Gy) and TBI (5Gy). GVHD (grade 1), hemorrhage cystitis and varicella occurred after BMT but were cured. His performance status is now 100% on the Karnofsky score at 10 months after BMT.
由于骨髓移植排斥反应和移植物抗宿主病（GVHD），非亲缘骨髓移植（BMT）的效果较差。然而，据报道，强化免疫抑制预处理方案联合全身照射（TBI）可降低排斥反应的发生率。我们报告了一例18岁重度再生障碍性贫血男性患者，他接受了来自非亲缘供者的匹配BMT。预处理方案包括环磷酰胺（50mg/kg）连续4天、全淋巴照射（TLI：6Gy）和TBI（5Gy）。BMT后发生了GVHD（1级）、出血性膀胱炎和水痘，但均治愈。在BMT后10个月，他的卡诺夫斯基评分显示其身体状况为100%。
