Isogai N, Kuroso K, Fujimaki M, Yorifuji H, Fukutake K
Department of Clinical Pathology, Tokyo Medical College.
Rinsho Byori. 1993 Dec;41(12):1349-52.
Ten patients with disseminated intravascular coagulation syndrome (DIC) were analyzed using three enzyme linked immunosorbent assays (ORGANON TEKNIKA, Belgium) for fibrin degradation products (FbDP), fibrinogen degradation products (FgDP) and total fibrin/fibrinogen degradation products (TDP). A significant elevation in each parameter and a significant depression of FgDP/FbDP (g/b) ratio were observed in the patients in early stage of DIC, comparing with normal individuals (p < 0.001 and p < 0.01). These results suggested that both fibrinolysis and fibrinogenolysis were marked accelerated, with a superiority in fibrinolysis in those patients. The levels of these parameters decreased and the g/b ratio increased with the passage of the clinical courses in five patients who were improved. Although in five deteriorated cases, the levels were kept high and their g/b ratio showed low continuously. These findings suggested that separated monitoring of fibrinolysis or fibrinogenolysis was useful to study patients with DIC and g/b ratio could be regarded as a helpful indication of therapeutic effects.
采用三种酶联免疫吸附测定法（比利时欧加农公司生产）对10例弥散性血管内凝血综合征（DIC）患者进行纤维蛋白降解产物（FbDP）、纤维蛋白原降解产物（FgDP）和总纤维蛋白/纤维蛋白原降解产物（TDP）分析。与正常个体相比，DIC早期患者各参数显著升高，FgDP/FbDP（g/b）比值显著降低（p<0.001和p<0.01）。这些结果提示，这些患者的纤溶和纤维蛋白原溶解均显著加速，且纤溶更为突出。在病情好转的5例患者中，随着病程进展，这些参数水平下降，g/b比值升高。而在5例病情恶化的患者中，这些参数水平持续保持高位，g/b比值持续较低。这些发现提示，对纤溶或纤维蛋白原溶解进行单独监测有助于研究DIC患者，g/b比值可作为治疗效果的有用指标。
