Yasukawa K, Kamijou Y, Momose G, Kobayashi S, Kuroyanagi T, Morota N, Unoki T
Kobayashi Neurosurgical and Neurological Hospital.
No Shinkei Geka. 1994 Jan;22(1):17-22.
Among 48 cases of subarachnoid hemorrhage, 21 cases (43.8%) showed symptomatic vasospasm. We attempted treatment, using a large amount of steroid therapy for them in accord with our own protocol. In the 21 cases who received steroid therapy for symptomatic vasospasm, 18 cases (85.7%) showed improvement of their symptoms. This was especially evident in about 8 cases where the steroid effect was remarkable. There was a serious side effect, GI--tract bleeding, in one case. Although the effect of the steroid therapy was evident for slight or moderate spasm cases, 5 severe spasm cases responded poorly. We concluded that a large amount of steroid therapy was effective for slight or moderate symptomatic vasospasm cases, and that in severe ones possibly another therapy combined with steroid therapy would be necessary.
在48例蛛网膜下腔出血患者中，21例（43.8%）出现症状性血管痉挛。我们按照自己的方案，对他们尝试使用大量类固醇疗法进行治疗。在接受类固醇疗法治疗症状性血管痉挛的21例患者中，18例（85.7%）症状有所改善。这在约8例类固醇效果显著的患者中尤为明显。有1例出现了严重的副作用，即胃肠道出血。尽管类固醇疗法对轻度或中度痉挛病例效果明显，但5例严重痉挛病例反应不佳。我们得出结论，大量类固醇疗法对轻度或中度症状性血管痉挛病例有效，而对于严重病例，可能需要联合其他疗法与类固醇疗法。
