大鼠连续和间歇性冷水游泳之间的抗伤害感受和体温过低交叉耐受性。

Antinociceptive and hypothermic crosstolerance between continuous and intermittent cold-water swims in rats.

作者信息

Pavlovic Z, Bodnar R J

机构信息

Department of Psychology, Queens College, City University of New York, Flushing 11367.

出版信息

Physiol Behav. 1993 Dec;54(6):1081-4. doi: 10.1016/0031-9384(93)90328-d.

DOI:10.1016/0031-9384(93)90328-d

PMID:8295944

Abstract

Antinociceptive responses induced by continuous (CCWS: 2 degrees C, 3 min) and intermittent (ICWS: 2 degrees C, 18 10-s swims, 18 10-s recoveries) cold-water swims differ in their sensitivity to opioid antagonists and crosstolerance with morphine. The present study examined whether CCWS and ICWS antinociception and hypothermia displayed crosstolerance in rats. Jump thresholds were significantly increased following acute exposure to CCWS (30 min) and ICWS (30-60 min). CCWS antinociception displayed tolerance (90% reduction) to CCWS after 14 days and crosstolerance (100% reduction) to ICWS on the fifteenth day. ICWS antinociception displayed tolerance (74% reduction) to ICWS and crosstolerance (81% reduction) to CCWS. Core body temperatures were significantly decreased following acute exposure to CCWS (30 min) and ICWS (30-90 min). Although CCWS and ICWS hypothermia displayed tolerance to the same stressor and crosstolerance to the other stressor, the changes in the antinociceptive and hypothermic effects failed to correlated significantly with each other.

摘要

持续（CCWS：2摄氏度，3分钟）和间歇（ICWS：2摄氏度，18次10秒游泳，18次10秒恢复）冷水游泳诱导的抗伤害感受反应对阿片类拮抗剂的敏感性以及与吗啡的交叉耐受性存在差异。本研究考察了CCWS和ICWS的抗伤害感受和体温过低在大鼠中是否表现出交叉耐受性。急性暴露于CCWS（30分钟）和ICWS（30 - 60分钟）后，跳跃阈值显著升高。CCWS抗伤害感受在14天后对CCWS表现出耐受性（降低90%），在第15天对ICWS表现出交叉耐受性（降低100%）。ICWS抗伤害感受对ICWS表现出耐受性（降低74%），对CCWS表现出交叉耐受性（降低81%）。急性暴露于CCWS（30分钟）和ICWS（30 - 90分钟）后，核心体温显著降低。尽管CCWS和ICWS体温过低对相同应激源表现出耐受性，对另一种应激源表现出交叉耐受性，但抗伤害感受和体温过低效应的变化彼此之间未显示出显著相关性。