Cole O F, Sullivan M H, Elder M G
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Prostaglandins. 1993 Dec;46(6):493-8. doi: 10.1016/0090-6980(93)90068-i.
In many systems the interleukin-1 receptor antagonist opposes the effects of interleukin-1 beta. We considered that it might block interleukin-1 beta-stimulated prostaglandin production from human decidual cells. Very high levels of interleukin-1 receptor antagonist (> 1000 pg/ml) had limited inhibitory effects on IL-1 beta-stimulated PGE2 synthesis, and lower levels of antagonist (< 1000 pg/ml) increased the effects of IL-1 beta. Low concentrations of the antagonist alone (1-100 pg/ml) increased basal PGE2 production, whereas higher levels (10-100 ng/ml) had less effect. It seems, therefore, that in human decidua the "antagonist" is more accurately described as a partial agonist. It has been suggested that the IL-1 receptor antagonist could be used to inhibit decidual prostaglandin synthesis and thereby prevent preterm labor, but this report shows that caution should be exercised before using the receptor antagonist.
在许多系统中，白细胞介素-1受体拮抗剂可对抗白细胞介素-1β的作用。我们认为它可能会阻断白细胞介素-1β刺激人蜕膜细胞产生前列腺素。非常高浓度的白细胞介素-1受体拮抗剂（>1000 pg/ml）对白细胞介素-1β刺激的PGE2合成的抑制作用有限，而较低浓度的拮抗剂（<1000 pg/ml）则增强了白细胞介素-1β的作用。单独使用低浓度的拮抗剂（1-100 pg/ml）可增加基础PGE2的产生，而较高浓度（10-100 ng/ml）的作用则较小。因此，在人蜕膜中，“拮抗剂”更准确地应被描述为部分激动剂。有人提出白细胞介素-1受体拮抗剂可用于抑制蜕膜前列腺素的合成，从而预防早产，但本报告表明在使用该受体拮抗剂之前应谨慎行事。
