Parazzini F, La Vecchia C, Negri E, Tozzi L
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italia.
Rev Epidemiol Sante Publique. 1993;41(6):480-6.
We analysed determinants of hysterectomy and oophorectomy using data from hospital control subjects, interviewed in a large case-control study on risk factors for breast cancer, conducted since 1983 in the Greater Milan area, Italy. Out of the 2916 women interviewed 355 (12.2%) were hysterectomized. Mean age at hysterectomy was 52. The cumulative probability of hysterectomy was similar in women born during the periods from 1900 to 1909 and 1910 to 1919. It rose steadily in each subsequent cohort for all ages till the cohort born between 1930 and 1939, then decreased in the cohort born between 1940 and 1949. The cumulative probability of hysterectomy by 60 years of age was 12.8% in women born between 1900 and 1909, and of 9.8%, 16.7% and 22.0% respectively in subsequent cohorts. Concerning determinants of hysterectomy, we found no relation with education and parity. Among the 355 hysterectomized women, 178 (50.1%) underwent unilateral (40 women) or bilateral (138 women) oophorectomy. The probability of oophorectomy was higher in more educated women. Compared with women who had had hysterectomy before the age of 45, those aged between 45 and 54 reported more frequently oophorectomy (odds ratio (OR): 1.5, 95% confidence interval (CI) from 0.9 to 2.3), but the OR was only 0.8 in those aged 55 or more (95% CI from 0.3 to 2.2). We found no relation between menopausal status or cohort of birth and oophorectomy.
我们利用来自医院对照受试者的数据，分析了子宫切除术和卵巢切除术的决定因素。这些数据来自于1983年以来在意大利大米兰地区进行的一项关于乳腺癌危险因素的大型病例对照研究中接受访谈的对照受试者。在接受访谈的2916名女性中，有355名（12.2%）接受了子宫切除术。子宫切除时的平均年龄为52岁。1900年至1909年期间出生的女性与1910年至1919年期间出生的女性子宫切除术的累积概率相似。在随后的各个年龄组中，累积概率稳步上升，直到1930年至1939年出生的年龄组，然后在1940年至1949年出生的年龄组中下降。60岁时子宫切除术的累积概率在1900年至1909年出生的女性中为12.8%，在随后的年龄组中分别为9.8%、16.7%和22.0%。关于子宫切除术的决定因素，我们发现其与教育程度和产次无关。在355名接受子宫切除术的女性中，有178名（50.1%）接受了单侧（40名女性）或双侧（138名女性）卵巢切除术。受教育程度较高的女性接受卵巢切除术的概率更高。与45岁之前接受子宫切除术的女性相比，45岁至54岁的女性报告接受卵巢切除术的频率更高（优势比（OR）：1.5，95%置信区间（CI）为0.9至2.3），但55岁及以上女性的OR仅为0.8（95%CI为0.3至2.2）。我们发现绝经状态或出生队列与卵巢切除术之间没有关联。
