Burow W
Psychiatr Neurol Med Psychol Beih. 1975;20-21:130-3.
In experimental observations the reaction of anger in cats was tested under the effects of psychotropic drugs. They were inhibited by chlopromazine and trifluoperazine. An even stronger effect on the emotional and in addition on the reaction of aggression is produced by haloperidol. By electrical and chemical stimulation of the anterior section of the hypothalamus and the central substantia grisea the evoked fit of emotion, as regards the vegetative and motor manifestations is repressed by all three preparations; but not as regards the specific components of the anger reaction, like growling and spitting. In further experiments chlorpromazine, trifluoperazine and haloperidol were injected into the nucleus amygdalae and in the nucleus caudatus. This resulted in a pronounced tropism in the amygdaloid nucleus, and a lesser tropism in the nucleus caudatus with the neuroleptica of the phenothiazine type. Haloperidol, on the other hand, did not effect the activity of the nucleus amygdalae and creates an obvious tropism in the nucleus caudatus.
在实验观察中，研究了精神药物作用下猫的愤怒反应。氯丙嗪和三氟拉嗪可抑制这种反应。氟哌啶醇对情绪以及攻击反应的影响更强。通过电刺激和化学刺激下丘脑前部和中央灰质，这三种制剂均可抑制由植物性和运动性表现所诱发的情绪发作；但对于愤怒反应的特定成分，如咆哮和吐口水，则无抑制作用。在进一步的实验中，将氯丙嗪、三氟拉嗪和氟哌啶醇注射到杏仁核和尾状核中。这导致了在杏仁核中有明显的嗜性，而对于吩噻嗪类抗精神病药，在尾状核中的嗜性较小。另一方面，氟哌啶醇对杏仁核的活性没有影响，却在尾状核中产生明显的嗜性。
