Dambacher M A, Felder M, Keller A, Neff M
Orthopädische Universitätsklinik Balgrist, Zürich.
Schweiz Rundsch Med Prax. 1994 Jan 18;83(3):79-83.
Today, bone density can be measured by different technical methods which show variations in terms of reproducibility, accuracy and sensibility. A crucial parameter is the reproducibility, which differs considerably from method to method. With densitometric methods it is possible not only to evaluate patients at risk getting an osteoporosis but also to establish an individual prophylaxis and therapy by means of highly precise quantitative methods, based on the parameters 'bone density' and 'loss of bone density'. A high bone turnover leads to fast bone loss and, vice versa, fast bone loss, measured by densitometry, is correlated with high bone turnover in postmenopausal women. This allows to establish an individual therapy with antiresorption resp. bone-stimulating agents and the knowledge about a tailored, individual treatment increases patients' compliance and reduces the rate of 'non-responders'.
如今，骨密度可通过不同的技术方法进行测量，这些方法在可重复性、准确性和敏感性方面存在差异。一个关键参数是可重复性，不同方法之间差异很大。使用骨密度测量方法，不仅可以评估有患骨质疏松症风险的患者，还可以基于“骨密度”和“骨密度损失”参数，通过高度精确的定量方法制定个性化的预防和治疗方案。高骨转换率会导致快速的骨质流失，反之，通过骨密度测量法测得的快速骨质流失与绝经后女性的高骨转换率相关。这使得可以制定抗吸收或促骨生成药物的个性化治疗方案，并且对量身定制的个性化治疗的了解提高了患者的依从性，降低了“无反应者”的比例。
