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[神经过敏性疾病的实验性预防与抑制]

[Experimental prevention and suppression of neuroallergic diseases].

作者信息

Hitzschke B, Meyer-Rienecker H J, Günther J

出版信息

Psychiatr Neurol Med Psychol Beih. 1975;20-21:17-22.

PMID:829617
Abstract

For concepts of therapy for neuro-allergic diseases, especially of the encephalomyelitis disseminata type the experimental allergic encephalomyelitis (EAEM)--as a neuro-immunological disease of the first order and a classic pattern for the specification of immunological processes--can be used for more and more extensive testing. After an exposition of the different forms of treatment (prevention, suppression and therapy) and their value the possibility of inducing tolerance a versus the encephalitogenic protein is discussed following the EAEM example--taking the view that all measures taken up to now in the case of neuro-allergic diseases have been unspecific and consequently not set down. In addition emphasis was laid on the assumption of tolerance induction after sensitization which is important to the formation of a therapy for encephalomyelitis disseminata.

摘要

对于神经过敏性疾病的治疗概念,尤其是播散性脑脊髓炎类型的,实验性过敏性脑脊髓炎(EAEM)——作为一级神经免疫疾病和免疫过程特异性的经典模式——可用于越来越广泛的测试。在阐述了不同的治疗形式(预防、抑制和治疗)及其价值之后,以EAEM为例讨论了诱导对致脑炎性蛋白的耐受性的可能性——认为迄今为止在神经过敏性疾病中采取的所有措施都是非特异性的,因此尚未确定。此外,强调了致敏后诱导耐受性的假设,这对播散性脑脊髓炎治疗方法的形成很重要。

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