Dujić Z, Eterović D, Tocilj J
Department of Physiology, Zagreb University School of Medicine in Split, Croatia.
Scand J Work Environ Health. 1993 Oct;19(5):346-51. doi: 10.5271/sjweh.1464.
This study reports an association between pleural plaques and resting hyperventilation in a group of workers exposed to asbestos. Information on exposure level, pack-years of cigarette smoking, chest radiographs, ventilation parameters, single-breath diffusing lung capacity, and arterial gases were obtained for 344 workers. After the exclusion of 37 workers for isolated parenchymal fibrosis, combined pleuroparenchymal fibrosis, or diffuse pleural thickening, 55 subjects with isolated pleural plaques were evaluated against 252 no-plaque workers. A quantitative pleural score revealed mild pleural disease. Forty-four workers with plaques (80%) had hypocapnia induced by resting hyperventilation. The quantitative pleural score correlated significantly with the partial pressure of carbon dioxide in arterial blood (correlation coefficient = 0.7). A decrement in forced vital capacity was associated with plaques, whether controlled for age, smoking, and exposure or not. It was concluded that the resting hyperventilation observed in some asbestos-exposed subjects is related to the presence of mild pleural plaques and a restrictive disorder.
本研究报告了一组接触石棉的工人中胸膜斑与静息时通气过度之间的关联。收集了344名工人的接触水平、吸烟包年数、胸部X光片、通气参数、单次呼吸肺弥散量和动脉血气等信息。在排除37名患有孤立性实质纤维化、合并性胸膜实质纤维化或弥漫性胸膜增厚的工人后，对55名患有孤立性胸膜斑的受试者和252名无胸膜斑的工人进行了评估。定量胸膜评分显示为轻度胸膜疾病。44名有胸膜斑的工人（80%）因静息时通气过度导致低碳酸血症。定量胸膜评分与动脉血二氧化碳分压显著相关（相关系数 = 0.7）。无论是否对年龄、吸烟和接触情况进行控制，用力肺活量的降低都与胸膜斑有关。研究得出结论，在一些接触石棉的受试者中观察到的静息时通气过度与轻度胸膜斑的存在及限制性疾病有关。
