Liberman I S, Ivanova S B, Stroev Iu I
Ter Arkh. 1993;65(10):42-6.
Lipid metabolism and lipid peroxidation (LPO) were studied in residents of St. Petersburg (healthy subjects without atherosclerosis history, healthy relatives of atherosclerotic patients, postmyocardial infarction patients, post-apoplectic patients and coronary heart disease sufferers) versus matched subjects living in rural area. Altogether 215 patients were examined. Besides genotype factors, lipid metabolism and LPO were found responsive to environmental factors. These were especially potent in changing the activity of superoxide dismutase, glutathione peroxidase, catalase. In those living in the country myeloperoxidase, superoxide dismutase and catalase activity was higher than in city population. The latter exhibited, though, higher activity of glutathione peroxidase. It is evident that more advantageous ecological conditions have distinct antiatherogenic action on lipid metabolism and LPO, especially, suggesting possible treatment of atherosclerosis by moving to more healthy locality as regards environmental pollution.
对圣彼得堡居民（无动脉粥样硬化病史的健康受试者、动脉粥样硬化患者的健康亲属、心肌梗死后患者、中风后患者和冠心病患者）以及生活在农村地区的匹配受试者的脂质代谢和脂质过氧化（LPO）进行了研究。共检查了215名患者。除了基因型因素外，发现脂质代谢和LPO对环境因素有反应。这些因素在改变超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢酶的活性方面尤为显著。生活在农村的人群中，髓过氧化物酶、超氧化物歧化酶和过氧化氢酶的活性高于城市人群。不过，城市人群的谷胱甘肽过氧化物酶活性较高。显然，更有利的生态条件对脂质代谢和LPO具有明显的抗动脉粥样硬化作用，特别是这表明通过搬到环境污染方面更健康的地区可能对动脉粥样硬化进行治疗。
