[Long term therapy with nitrazepam in children with infantile spasms and myoclonic-astatic fits].

Since 1968 54 children with infantile convulsion and myoclonic-static fits have been treated with RADEDORM (minimum dosage 2x1/2 tablets, maximum 1--1,5 mg/kg body weight) in the Neuropediatric department of the University Pediatric Clinic in Leipzig. Most of the patients showed a retarded statical and mental development, 50% pathological neurological results. The results of the therapy (35% free of attacks; in 20% a reduction in frequency of attacks of 75--99%; in 6% of 50--74%, in 39% less than 50%, respectively no effect) can be said to be good. Myoclonic-astatic fits were semowhat less favourably influenced than infantile-convulsions. A combination with grand mal epilepsy also had a negative effect on such cases. The results of the treatment were independent of intelligence and duration of illness, however they were not so good in infants as in young children. The electroencephalogram showed with little exception a considerable conformity with the results of the treatment. The side-effects were relatively small and only seldom demanded a reduction in dosage.