[重组人粒细胞集落刺激因子治疗周期性中性粒细胞减少症。周期性中性粒细胞减少症的连续与间歇重组人粒细胞集落刺激因子治疗]
[rhG-CSF treatment in cyclic neutropenia. Continuous versus intermittent rhG-CSF treatment in cyclic neutropenia].
作者信息
Nielsen H, Hansen P B
机构信息
Medicinsk haematologisk afdeling L. Københavns Amts Sygehus i Herlev.
出版信息
Ugeskr Laeger. 1994 Jan 17;156(3):324-5.
PMID:8296427
Abstract
Cyclic neutropenia is a stem-cell disorder characterized by regular 21-day cyclic fluctuations in the number of neutrophils in the blood and bone marrow. The neutropenic periods may be complicated by fever, stomatitis and severe infections. In this case report only daily continuous and later intermittent treatment with recombinant human granulocyte colony-stimulating factor (two micrograms/kg) administered subcutaneously effectively prevented recurrent infections.
摘要
周期性中性粒细胞减少症是一种干细胞疾病，其特征是血液和骨髓中中性粒细胞数量呈规律的21天周期性波动。中性粒细胞减少期可能会并发发热、口腔炎和严重感染。在本病例报告中，仅通过每日持续皮下注射重组人粒细胞集落刺激因子（2微克/千克），随后改为间歇性注射，有效预防了反复感染。
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