缺失gp41的重组痘苗病毒锚定gp120的免疫原性增强。

Improved immunogenicity of recombinant vaccinia virus-anchored gp120 lacking gp41.

作者信息

Jin Y, Giri C, Klutch M J, Shepp D, Wright S E

机构信息

Department of Internal Medicine, Texas Tech University Health Sciences Center.

出版信息

Vaccine. 1993 Oct;11(13):1280-2. doi: 10.1016/0264-410x(93)90095-f.

DOI:10.1016/0264-410x(93)90095-f

Abstract

To produce a vaccine against human immunodeficiency virus-1 with improved immunogenicity, the transmembrane and cytoplasmic tail regions of human immunodeficiency virus-1 were replaced with those of the Vesicular Stomatitis Virus glycoprotein, and cloned into vaccinia virus. This recombinant vaccinia virus, vvE13, was compared to one expressing full length envelope gp160, vvE1. Env products of both were located on the cell surface. Antibody response, lymphocyte proliferation and cytotoxicity were better with vvE13 than with vvE1 inoculated mice.

摘要

为生产一种具有更高免疫原性的抗人类免疫缺陷病毒-1疫苗，将人类免疫缺陷病毒-1的跨膜区和胞质尾区替换为水疱性口炎病毒糖蛋白的相应区域，并克隆到痘苗病毒中。将这种重组痘苗病毒vvE13与一种表达全长包膜糖蛋白gp160的病毒vvE1进行比较。两者的Env产物均位于细胞表面。接种vvE13的小鼠在抗体反应、淋巴细胞增殖和细胞毒性方面比接种vvE1的小鼠表现更好。

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