Riera de Martínez Villa N, Torres de Mercau G, Martínez Riera N, Soria de Santos N, Vitalone H
Cátedra de Toxicología, Facultad de Medicina, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
Acta Gastroenterol Latinoam. 1993;23(3):159-63.
The aim of the present paper is to show lead toxicity and cell deposition of concentrations lower than those regarded as toxic on an experimental model with rats C3Hs., forty five grams-rats were used. A standard diet was administered together with water ad-libitium, containing very low doses of lead acetate which was constantly administered and at fixed periods. Light and electron microscopy were used to study the liver and the spleen. These organs are considered to harbour a great amount of constant macrophages with phagocytic function. The findings showed lesions and lead deposits which confirmed the causative agent as well as its toxic contaminating action.
本文的目的是在C3Hs大鼠实验模型上展示低于通常认为有毒浓度的铅毒性和细胞沉积情况。使用了体重45克的大鼠。给予标准饮食并随意饮水，饮食中含有持续且定期给予的极低剂量醋酸铅。采用光镜和电镜研究肝脏和脾脏。这些器官被认为含有大量具有吞噬功能的常驻巨噬细胞。研究结果显示了病变和铅沉积，证实了致病因子及其毒性污染作用。
