在棕色挪威（BN）、刘易斯和威斯塔京都（WKY）大鼠品系中诱导针对人及大鼠髓过氧化物酶（MPO）的体液和细胞（自身）免疫反应。
Induction of an humoral and cellular (auto) immune response to human and rat myeloperoxidase(MPO) in Brown-Norway(BN), Lewis and Wistar Kyoto(WKY) rat strains.
作者信息
Brouwer E, Weening J J, Klok P A, Huitema M G, Tervaert J W, Kallenberg C G
机构信息
Dept. Clinical Immunology, University Hospital, Groningen, The Netherlands.
出版信息
Adv Exp Med Biol. 1993;336:139-42. doi: 10.1007/978-1-4757-9182-2_24.
Anti-MPO and anti-proteinase 3 antibodies are strongly associated with certain forms of vasculitis and glomerulonephritis and a pathophysiological role for the antibodies has been hypothesized (Kallenberg et al. 1991). To test this hypothesis WKY, Lewis and BN rats were immunized with human MPO. BN rats developed a strong humoral response, cross reacting with autologous MPO, and Lewis rats a strong cellular response to human MPO.
抗髓过氧化物酶（MPO）抗体和抗蛋白酶3抗体与某些形式的血管炎和肾小球肾炎密切相关，并且已经推测这些抗体具有病理生理作用（卡伦伯格等人，1991年）。为了验证这一假设，将WKY、Lewis和BN大鼠用人MPO进行免疫。BN大鼠产生了强烈的体液反应，与自身MPO发生交叉反应，而Lewis大鼠对人MPO产生了强烈的细胞反应。
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