Kövér G, Tost H, Tarkovács G
Acta Physiol Acad Sci Hung. 1976;48(1):87-93.
Renal function was tested after decreasing the plasma ionized calcium level of renal artery. During EDTA infusion, renal blood flow (RBFdir) increased, while CPAH, Ccreat, EPAH and Ecreat decreased. In the left kidney, urinary and sodium excretion did not change significantly, while calcium excretion reached a fifteen-fold higher value than the control one. The unchanged urinary and sodium excretion in spite of the decreased glomerular filtration rate may have been due to the osmotic diuretic effect of the Ca-EDTA complex. The decrease of CPAH and EPAH was probably the consequence of a change in the secretory capacity in the absence of Ca++. the vasodilatation occurring in the efferent arterioles during EDTA infusion would serve to explain the decrease in the glomerular filtration rate. It is concluded that humoral vasoactive factors, mainly angiotensin, may have an important role in the regulation of the diameter of the efferent arterioles and in this way in the regulation of glomerular function.
在降低肾动脉血浆离子钙水平后对肾功能进行了检测。在输注乙二胺四乙酸（EDTA）期间，肾血流量（RBFdir）增加，而对氨基马尿酸清除率（CPAH）、肌酐清除率（Ccreat）、对氨基马尿酸排泄量（EPAH）和肌酐排泄量（Ecreat）降低。在左肾，尿和钠排泄无明显变化，而钙排泄量达到比对照值高15倍的值。尽管肾小球滤过率降低，但尿和钠排泄未变，这可能归因于Ca-EDTA复合物的渗透性利尿作用。CPAH和EPAH降低可能是在没有Ca++的情况下分泌能力改变的结果。EDTA输注期间出球小动脉发生的血管舒张可解释肾小球滤过率的降低。得出的结论是，体液血管活性因子，主要是血管紧张素，可能在出球小动脉直径的调节中以及以此方式在肾小球功能的调节中起重要作用。
