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促性腺激素释放激素拮抗剂对男性性腺功能调节的行为影响

Effects on behavior of modulation of gonadal function in men with gonadotropin-releasing hormone antagonists.

作者信息

Loosen P T, Purdon S E, Pavlou S N

机构信息

Department of Psychiatry, Vanderbilt University, Nashville, TN.

出版信息

Am J Psychiatry. 1994 Feb;151(2):271-3. doi: 10.1176/ajp.151.2.271.

DOI:10.1176/ajp.151.2.271
PMID:8296903
Abstract

The effects of acute gonadal suppression on sexual function and behavior were studied in eight normal men. Administration of a newly developed, potent gonadotropin-releasing hormone antagonist induced azoospermia and reduced levels of serum testosterone, luteinizing hormone, and follicle-stimulating hormone. These effects coincided with a reduction in outward-directed aggression in all men. Self-reported measures of anxiety and sexual desire revealed less consistent change over time. Measures of anger control, inward-directed anger, and affective state were unaffected.

摘要

在八名正常男性中研究了急性性腺抑制对性功能和行为的影响。给予一种新开发的强效促性腺激素释放激素拮抗剂可导致无精子症,并降低血清睾酮、促黄体生成素和促卵泡生成素水平。这些影响与所有男性外向攻击性的降低相一致。自我报告的焦虑和性欲测量结果显示,随着时间的推移变化不太一致。愤怒控制、内向愤怒和情感状态的测量结果未受影响。

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Effects on behavior of modulation of gonadal function in men with gonadotropin-releasing hormone antagonists.促性腺激素释放激素拮抗剂对男性性腺功能调节的行为影响
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Suppression of pituitary-gonadal function by a potent new luteinizing hormone-releasing hormone antagonist in normal men.一种强效新型促黄体生成激素释放激素拮抗剂对正常男性垂体-性腺功能的抑制作用。
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