Mälkki Y, Törrönen R, Pelkonen K, Myllymäki O, Hänninen O, Syrjänen K
Technical Research Centre of Finland, Food Research Laboratory, Espoo.
Br J Nutr. 1993 Nov;70(3):767-76. doi: 10.1079/bjn19930172.
Oat bran concentrated with respect to both soluble and insoluble dietary fibre was fed to adult rats, and its effects on serum cholesterol and liver fat infiltration were studied. The feeds contained 15, 30 or 45 g beta-glucan/kg, except in control groups where the fibre of the feed was cellulose. Half the experimental groups received the feeds with an addition of 10 g cholesterol and 2 g cholic acid/kg in order to create an hypercholesterolaemic condition. In normocholesterolaemic rats the concentrated oat bran did not cause any significant changes in serum cholesterol concentrations, but reduced liver weight compared with control group rats fed on the cellulose-containing diet. In hypercholesterolaemic rats the concentrated oat bran reduced serum total cholesterol and increased high-density-lipoprotein cholesterol concentration. The effect was seen already at the 15 g/kg concentration of beta-glucan, the higher doses tested did not significantly improve the effect. Infiltration of fat into liver cells, especially in the periportal areas, was observed only in hypercholesterolaemic animals. The fat infiltration was accentuated in proportion to the amount of oat-bran concentrate fed.
将富含可溶性和不可溶性膳食纤维的燕麦麸喂给成年大鼠，并研究其对血清胆固醇和肝脏脂肪浸润的影响。饲料中含有15、30或45克β-葡聚糖/千克，但对照组饲料中的纤维为纤维素。一半的实验组在饲料中添加了10克胆固醇和2克胆酸/千克，以造成高胆固醇血症状态。在正常胆固醇水平的大鼠中，浓缩燕麦麸不会引起血清胆固醇浓度的任何显著变化，但与喂食含纤维素饮食的对照组大鼠相比，肝脏重量减轻。在高胆固醇血症大鼠中，浓缩燕麦麸降低了血清总胆固醇并增加了高密度脂蛋白胆固醇浓度。在β-葡聚糖浓度为15克/千克时就已观察到这种效果，测试的更高剂量并未显著改善这种效果。仅在高胆固醇血症动物中观察到脂肪浸润到肝细胞中，尤其是在门周区域。脂肪浸润的程度与喂食的燕麦麸浓缩物的量成比例增加。
