Bronson R T, Lipman R D
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts.
Aging (Milano). 1993 Aug;5(4):253-7. doi: 10.1007/BF03324169.
The distinction between aging and age-related disease is a blurred one at best. Pathologic lesions and diseases, while having obvious importance for the well-being of an individual, are not more indicative of aging than are silent or benign aging changes. All lesions are useful as biomarkers of aging. They are definable, and can be characterized in terms of their prevalence and severity in different species, genotypes, genders, and age groups. Some data from previous studies are presented as examples. Many lesions of aging are quite restricted, in terms of prevalence or severity, to specific genotypes, species or genders. Recognition of the very great diversity of lesion biomarkers between genotypes, genders and species should prevent investigators from extrapolating findings in one genotype-gender to any other.
衰老与年龄相关疾病之间的区别充其量只是模糊不清的。病理病变和疾病虽然对个体的健康有着明显的重要性，但与沉默或良性的衰老变化相比，它们并非更能指示衰老。所有病变都可作为衰老的生物标志物。它们是可定义的，并且可以根据其在不同物种、基因型、性别和年龄组中的患病率和严重程度进行特征描述。文中给出了一些先前研究的数据作为示例。就患病率或严重程度而言，许多衰老病变在特定基因型、物种或性别中相当有限。认识到基因型、性别和物种之间病变生物标志物的巨大差异，应防止研究人员将一种基因型-性别的研究结果外推至任何其他情况。
