Sprott R L
Biology of Aging Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Exp Gerontol. 1997 Jan-Apr;32(1-2):79-86. doi: 10.1016/s0531-5565(96)00035-6.
There are advantages and disadvantages to all animal models for aging research. Investigators need to understand these issues, as well as the nature of each relevant model, to choose the best model for their research. There is no, "best" or "worst" model for aging research. Five genetically defined rodent models of potential utility in aging research are: (1) inbred strains and F1 hybrid mice and rats, (2) single gene mutations and other single locus effects, (3) congenic lines, (4) recombinant Inbred (RI) strains, and (5) genetically selected strains and stocks. Animals of each of these types are available for research, but only inbred and F1 hybrid mice and rats are commercially available as aged animals. A genetic understanding of the need for careful genetic definition and for the best available barriér-breeding facilities has improved the quality of aging research significantly in the last one decades.
所有用于衰老研究的动物模型都有其优缺点。研究人员需要了解这些问题以及每个相关模型的特性，以便为他们的研究选择最佳模型。对于衰老研究而言，不存在“最佳”或“最差”的模型。在衰老研究中可能有用的五种基因定义的啮齿动物模型是：（1）近交系和F1杂交小鼠及大鼠，（2）单基因突变和其他单基因座效应，（3）同源近交系，（4）重组近交（RI）系，以及（5）基因选择的品系和种群。每种类型的动物都可用于研究，但只有近交系和F1杂交小鼠及大鼠作为老龄动物有商业供应。在过去十年中，对仔细的基因定义以及最佳可用屏障饲养设施需求的遗传学理解显著提高了衰老研究的质量。
