Feldman S, Weidenfeld J
Department of Neurology, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Neuroreport. 1993 Dec 13;5(3):258-60. doi: 10.1097/00001756-199312000-00019.
The effects of depletion of hypothalamic norepinephrine (NE) on median eminence (ME)-corticotropin-releasing factor (CRF-41) content, serum ACTH and corticosterone (CS) levels, following photic and acoustic stimulation, were investigated. While in intact rats these stimuli caused depletion in CRF-41 and a rise in ACTH and CS level, in rats pretreated with 6-hydroxydopamine (6-OHDA), these effects were prevented. This would suggest that the blockage in the release of ME CRF-41 into the portal plasma following neural stimuli in rats with hypothalamic NE depletion, is responsible for the inhibition of the pituitary-adrenocortical response.
研究了下丘脑去甲肾上腺素（NE）耗竭对光和声刺激后正中隆起（ME）-促肾上腺皮质激素释放因子（CRF-41）含量、血清促肾上腺皮质激素（ACTH）和皮质酮（CS）水平的影响。在完整大鼠中，这些刺激导致CRF-41耗竭以及ACTH和CS水平升高，而在预先用6-羟基多巴胺（6-OHDA）处理的大鼠中，这些效应被阻止。这表明，下丘脑NE耗竭的大鼠在神经刺激后ME CRF-41释放到门静脉血浆中的受阻，是垂体-肾上腺皮质反应受到抑制的原因。
