下丘脑去甲肾上腺素耗竭会抑制神经刺激后促肾上腺皮质激素释放因子41的释放。
Hypothalamic norepinephrine depletion inhibits CRF-41 release following neural stimuli.
作者信息
Feldman S, Weidenfeld J
机构信息
Department of Neurology, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
出版信息
Neuroreport. 1993 Dec 13;5(3):258-60. doi: 10.1097/00001756-199312000-00019.
The effects of depletion of hypothalamic norepinephrine (NE) on median eminence (ME)-corticotropin-releasing factor (CRF-41) content, serum ACTH and corticosterone (CS) levels, following photic and acoustic stimulation, were investigated. While in intact rats these stimuli caused depletion in CRF-41 and a rise in ACTH and CS level, in rats pretreated with 6-hydroxydopamine (6-OHDA), these effects were prevented. This would suggest that the blockage in the release of ME CRF-41 into the portal plasma following neural stimuli in rats with hypothalamic NE depletion, is responsible for the inhibition of the pituitary-adrenocortical response.
研究了下丘脑去甲肾上腺素（NE）耗竭对光和声刺激后正中隆起（ME）-促肾上腺皮质激素释放因子（CRF-41）含量、血清促肾上腺皮质激素（ACTH）和皮质酮（CS）水平的影响。在完整大鼠中，这些刺激导致CRF-41耗竭以及ACTH和CS水平升高，而在预先用6-羟基多巴胺（6-OHDA）处理的大鼠中，这些效应被阻止。这表明，下丘脑NE耗竭的大鼠在神经刺激后ME CRF-41释放到门静脉血浆中的受阻，是垂体-肾上腺皮质反应受到抑制的原因。
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