Vandenbroucke A, Bourdon C
Unité de Prévention et Dépistage du Cancer ESP Bte 3051, Bruxelles, Belgium.
Eur J Cancer Prev. 1993 Nov;2 Suppl 3:3-10.
DCIS and LCIS are different breast diseases at various points of view. DCIS has in most cases a clinical or mammographical pattern, whereas LCIS represents an incidental finding in breast tissue removed for another reason. However, DCIS found incidental to benign disease may be a more innocuous form of tumour. Multifocal foci are more frequent in LCIS than in DCIS, but microinvasion and coexisting unsuspected infiltration carcinoma are more often found in DCIS. Contralateral in situ breast carcinoma is a rare event in DCIS. It is seldom found in LCIS. The risk of development of an infiltrating ipsilateral carcinoma after biopsy or excision showing in situ carcinoma is higher for DCIS than for LCIS. However, in most cases the invasive tumour occurs at or near the site of the original biopsy. Among LCIS patients, invasive carcinoma occurs anywhere in the breast parenchyma. The risk of development of contralateral invasive cancer is very low in DCIS patients, but it is high in LCIS patients. It may be lobular, ductal or a mixture of different types. DCIS has to be considered as a truly preinvasive lesion although LCIS is rather a marker of increased risk.
从多个角度来看，导管原位癌（DCIS）和小叶原位癌（LCIS）是不同的乳腺疾病。在大多数情况下，DCIS具有临床或乳腺X线摄影表现，而LCIS是在因其他原因切除的乳腺组织中偶然发现的。然而，在良性疾病中偶然发现的DCIS可能是一种较为无害的肿瘤形式。多灶性病灶在LCIS中比在DCIS中更常见，但微浸润和并存的未被怀疑的浸润性癌在DCIS中更常被发现。对侧乳腺原位癌在DCIS中是罕见事件，在LCIS中很少见。活检或切除显示原位癌后，DCIS发生同侧浸润性癌的风险高于LCIS。然而，在大多数情况下，浸润性肿瘤发生在原活检部位或其附近。在LCIS患者中，浸润性癌可发生在乳腺实质的任何部位。DCIS患者发生对侧浸润性癌的风险非常低，但LCIS患者的风险很高。它可能是小叶型、导管型或不同类型的混合。DCIS必须被视为真正的浸润前病变，尽管LCIS更像是风险增加的一个标志物。
